To support a study on quantifying differential vaccine efficacy in low- and high-income settings. The post-holder will coordinate the literature reviewing of vaccine trials and subsequent data collation, and finally will support modelling work and report generation.
REPORTS TO: Principal Investigator
DIRECTLY SUPERVISES: None
INDIRECTLY SUPERVISES: None
The KEMRI-Wellcome Trust Research Programme researches diseases with the highest burden in developing countries for which it is recognised internationally within the fields of international public health, clinical tropical medicine, epidemiology and immunology. The programme aims to maximise opportunities for learning and training in order to maintain a cadre of highly skilled and experienced staff from all disciplines.
Vaccination is recognised as a highly successful and cost-effective intervention. However, it has been observed for some vaccines that efficacy and effectiveness are lower when implemented in low-income countries relative to high-income settings (for example rotavirus vaccine). Vaccine trials are very expensive, and most are carried out first in the high-income setting. It would be beneficial economically and logistically to draw upon high-income country trial experience for designing trials in the low-income setting. Analysis of trials to date could be used to quantify the differential efficacy of vaccine in high-low income setting and hence provide more realistic targets for estimating sample sizes for future trials in low-income settings.
The advertised position will be to support a collaborative research project between University of Glasgow, UK and KEMRI-Wellcome Trust Research Programme. The study will involve a systematic review and hierarchical meta-regression to determine the frequency and magnitude with which vaccine efficacy differs across high/low income settings, and to identify which trial-level characteristics (eg vaccine, agent, host, etc) are associated with this differential efficacy.
The post holder will be based primarily in Kenya, but some time in the UK with our collaborators is envisaged. The job requires a meticulous, thorough and conscientious work ethic with strong communication and team skills facilitating successful collaboration with the Glasgow team. The successful applicant will (with minimal training) be capable of accurately extracting relevant numerical results (eg baseline characteristics and effect estimates) from clinical trial publications, and of harmonising results across trials for subsequent analysis. The successful applicant will learn skills in conducting systematic reviews including designing appropriate search criterion and extracting relevant data, data management and manipulation and statistical analyses including meta-analysis (some at advanced level).
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All applicants are required to state their current/last salary.
Candidates must supply an email and telephone contact that will be used when offering interviews. Only shortlisted candidates will be contacted. Shortlisted candidates shall be required to produce ORIGINALS of their National Identity Card, academic and professional certificates, original transcripts and testimonials, detailed curriculum vitae and valid clearance certificate (certificate of good conduct) during the interviews.
The application closing date is 17 September, 2019.
KEMRI-Wellcome Trust Research Programme (KWTRP) is an equal opportunity employer. Direct or indirect canvassing will lead to automatic disqualification. KWTRP does not charge a fee at any stage of the recruitment process (application, interview, meeting, processing, training or any other fees).
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